Ken Osumi

Reading the internal representations of protein language models to generate residue-level mechanistic hypotheses.

Package model docs

This document describes the kinetic models used to fit the binding curves in this package: for each model, the reaction scheme, the binding response, the system of…

9 min

Data — I Beat Claude on TNFα for $677

Both arms of both targets, the per-engine scores behind the selection, and the binding kinetics from Adaptyv Bio. Released under ODC-BY.

2 min

I Beat Claude on TNFα for $677

Seven of ten designs bound. Everything I used was public and free. The one step that mattered was written down in 2003.

Aug 21, 2026

8 min

Reproducing ESMC’s SAE features: I lost half a day to one wrong repo

Reproducing Figure S33 of the ESMC paper, solo. I picked the wrong one of two similarly-named SAEs, lost half a day, and came out the other side at the most interesting feature in the figure.

Jun 22, 2026

6 min

ESMC の SAE 図を一人で再現したら、repo の取り違えで半日溶かした話

ESMC 論文の Figure S33 を一人で再現した記録。よく似た名前の SAE を取り違えて半日ハマり、抜けた先で一番おもしろい特徴に行き着くまで。